Agree with most of this, but have to disagree with your comment that Holmes wasn't the primary focus of Indiana's offense last season. Last season (and this season too) she led them in PPG, FGA, FG%, USG%, and PER. And she was second (but essentially tied for first) in FGA. So I'm not sure it's possible how you could justify your claim statistically. Additionally, simply having her camped out as a scoring threat on the block creates the spacing that opens things up for the guards to drive.
Gulbe has been able to shoulder a bit more of the scoring load as of late, but she's a stretch 4, not a true 5. So that changes their offense a bit. Browne can set good screens and play good defense, but she's hardly a scoring threat on the block.