More realistically the matchup is probably going to be Cardoso vs. Edwards (I think that's a draw) since Kamila will get most of the minutes alongside Boston. Saxton likely wont get more than 10 minutes, Cardoso will get the bulk of the minutes.
I think the lineup matches are fun but miss a lot of context and there's still so much unknown. For example, Fudd is back but has been a shell of herself so far. Is she going to return to AA form in 2-3 weeks or is she going to be a B version of herself like Bueckers was for most of last year's postseason (aside from the NC State game)? Same with Ducharme.
Also, Zia Cooke is such a wild card for SC. She could outplay her counterpart, or get massively outplayed like she was last matchup. I think the only way UCONN or anyone else competes with SC is if they catch her on a cold shooting night and can bait her into 12-15 shots. It worked well for UCONN their last match up (she shot 2-15), but her offensive production just varies game by game.
And the bench can't be understated. Even if UCONN has players back, it's big advantage for SC primarily due to coaching style and post depth. Geno has never been one to use more than 6-7 players even with a deeper lineup. Patterson/Deberry aren't going to get a significant minutes unless there's significant foul trouble, where SC has Amihere/Saxton who will get minutes. SC can rest their main posts so they stay fresh without a ton of drop off and they just wear you down. We saw that in the last matchup and we've seen it from SC's opponents all year. I think it's still a pretty clear cut edge to SC overall but UCONN (and several other teams) are capable of pulling off an upset if they play well and have a few other factors go their way.