uconnfan 68, when you say "much different" as in it will be more difficult for Louisville, I agree.
According to the ESPN boxscores, the only person Louisville played against SC that didn't play against UConn was sophomore Anaya Hardy who started, played 24 minutes and had 6 points and 5 rebounds (along with four fouls). Her points and rebounds are pretty close to her season averages.
UConn, on the other hand, didn't have Blanca available for that first game. Furthermore, our bench against the Cardinals (Jana, Ice, Allie and K9) scored 16 points. Collectively, these four in the rotation now (I'm excluding Ice) average 28.5 points per game off the bench.