I think the ACC is going to be the reason the ACC breaks up. The half of the conference that takes football seriously (Miami, Clemson, FSU, NC State, Louisville, VT, and maybe one or two others) is going to bolt for the Big 12 as soon as it can. The rest will disperse in whichever direction the wind blows them (for the Big East's sake, hopefully it brings some of them back to their roots).
I don't think the SEC has any desire to expand more than a state or two beyond its existing footprint, if at all. I know that might be hard to believe in light of the B1G's imperialist takeover of the west coast, but I think SEC fans have stronger spines than B1G fans. They genuinely want the SEC to consist of southern teams and don't care as much about the business side of things.
As a UConn football fan, I'd rather be in a league where we can compete, anyway. If we stay patient and play our cards right, we could end up back in the same league as BC, Cuse, Pitt, etc. Throw in another couple schools like Temple, USF, and maybe some combination of Wake, ECU, UNC, GT, UVA, and you have a conference that actually makes sense. Hell, maybe even UMass. Remaining isolated and estranged from any natural rivalries is not the way to revive college football in the northeast.