UConn will be fine if the eventual end state is five 16 team conferences. However, what if the end state is four 16 team conferences? The ACC is the vulnerable prey now that the Big East has been killed off. It isn't out of the realm of possibility to see:
B1G : adds North Carolina, Virginia, Maryland, Notre Dame
SEC : adds Virginia Tech and NC State
B12 : adds FSU, Clemson, Georgia Tech, Louisville, Miami, Pittsburgh
In this scenario, each of the conferences are consolidating the power and money by killing off the ACC as well as expanding each of their geographic footprints to valuable markets (B1G would expand eastward and own everything north of the Mason Dixon line, the SEC would expand all the way up to DC, and the B12 would grab the key Southeast).
Then we would be stuck in the ACC with mostly private schools and would not be able to compete at all on the football field. Although, our Olympics (basketball) would be fine with the likes of Syracuse, BC, Duke, Wake Forest, Rutgers, etc.