Looking at 2 of the other powerhouse programs from the last 15-20 years:
Tennessee:
2001-lost reigning player of the year Tamika Catchings to an ACL mid year
2004-lost starting point guard Loree Moore mid year to an ACL
2005-Candace Parker, Sidney Spencer (starter), Alex Fuller, Sa'de Wiley-Gatewood all out with full season or season ending injuries
2006-Alexis Hornbuckle (4 year starter) injured mid year, left Tennessee without a point guard. She did come back in the tournament but was a shell of herself.
2009-Vicki Baugh tore her ACL in the title game and was recovering, then retears her ACL mid year. Projecting starting PG Cait McMahan retires due to injuries.
2010-projected starter Vicki Baugh is out all year recovering from ACL
2012-starter Kelley Cain retires before the season due to injuries (although she'd later declare for the draft and be a top 10 pick)
2014-lost starting PG Ariel Massengale to season ending injury
2015-lost leading score Izzy Harrison mid year to an ACL. Likely starter Mercedes Russell redshirts due to injury.
2020-Starter Zaay Green tears ACL early in year, out for season
2022-Starters Jordan Horston/Marta Suarez with season ending injuries. Rae Burrell missed the first 2 months and never found the same form from her previous breakout year. Rotation player Keyen Green also tears ACL.
Notre Dame:
(I don't know their program as well, but here are some of the marquee injuries):
2007: Starter Lindsay Schrader out with ACL
2008: Devereaux Peters with season ending ACL injury.
2009: Peters and Brittany Mallory with ACL injuries
2011: Kayla McBride leaves team mid year to deal with off court issues (not the same as an injury but worth noting)
2012: Madison Cable out all year with injuries
2014: lost starting All American center Natalie Achonwa to ACL in the NCAA tournament
2017: lost All American Brianna Turner to an ACL in the NCAA tournament
2018: lost 4 players to ACLs including All American Brianna Turner and Lili Thompson who played 27 mpg
2020: Anaya Peoples season ending injury, Abby Prohaska health problems and was out for the year
2021: Natalija Marshall out with ACL