I could see this happening in a very low scoring affair. Arizona is likely to fall in one of these poor shooting affairs.
I don't think it's going to happen, but the likelihood increased a bit with Lauren Ware's injury. Still, it's in McKale. It's an environment that few in WBB experience if they aren't South Carolina, Oregon, Oregon State, etc.
Besides, low-scoring isn't really a problem for Arizona. They're much better offensively this year, but being able to defend was the reason they succeeded the past 3 years.
More likely to knock off Arizona early are NAU (it's being played in Flagstaff) or Texas. Texas was supposed to have a home-and-home with Arizona but apparently used last year's COVID-19 cancelation to reneg on the return game. Arizona knocked them out of the Top 25 for the first time in years and had Aari McDonald drop 44 on them in Austin two years ago. It's going to be in Vegas and Ware might still be out then, so it could well go in the Longhorns' favor.