One of our cats has a congenital eye disease and has already lost one eye. We've prepared ourselves for the possibility that at some point we will have to have the other eye removed. From what everyone has told us, we expect she will do fine. It helps a lot that she has been in the house for a couple of years already and generally knows where things are. It helps that she will probably go blind slowly, so will get used to the idea of having things appear seemingly out of nowhere because of her limited vision. We've honestly been amazed at how well she has done with maybe 60% vision in only one eye, and figure she will do fine unless we move at some point in the future. That would be very hard, I think.