It is an interesting comparison looking at the first weekend teams.
UConn, Iona, VCU and SMC.
Iona and VCU have a combined three games against P6 teams (VCU lost against ASU and beat Pitt and Vandy). SMC has their games against the Zags and wins against Vandy/SDST and losses to Houston/Washington.
Iona/VCU/SMC have a combined 8 Q1 games this year with 3 wins.
On the other hand:
X, Kennesaw St, ISU and one of Pitt/Mississippi St.
Kennesaw State lost to UF, SDSU and Indiana (also a head to head to VCU by three). Then ISU who has 21 Q1 games and went 10-11 in those games. Not to mention another 5 games against P6 teams where they went 3-2. So 13-13 against top competition. Not great but they are tested and have a 50/50 shot of beating good teams, they swept Baylor and TCU, beat KU, beat Texas and beat KSU. Even Pitt has more Q1 wins than Iona/VCU and SMC combined. Same for Mississippi St.
Not saying UConn will win both games or that the teams in X's grouping are better but X has a much more battle tested group this first weekend.
IMO BTW South is the easiest region. The other three are all pretty even unless UConn plays to it's potential.