For me, as long as there only 7 or 8 players, game approach requires a new paradigm, as the current approach of 5-until-they-drop is clearly having more than just in-game effects. That everyone is mentally / physically drained is, again, for me, a self-inflicted wound. Sort of like, in a driving rainstorm, heading out without an umbrella, and fussing about getting drenched.
Point is, there are EIGHT available players, two of which are highly recruited scholarship resources, yet play meaningless minutes. Miss a shot, force a bad pass, back to the bench. One surmises, playing them each significant minutes, 15-20+ each, depending on the physical / mental condition of the starting 5, and opponent, would be better long term, for the well-being of the 5 as the season winds down. Once the injured players return, the minutes of the three can correspondingly decrease.
Results: healthier players, with the increased productivity from the bench players, through more reps.
Sure, results will suffer a bit in the short term. But after this past game, with all the postgame focus on fatigue, this seems one way to address it.