I checked, and unless I overlooked something, this is by far the biggest margin of loss for Syracuse all year. Louisville beat Syracuse twice by 13-point margins. NC State appears to have played Syracuse only once, at Syracuse, and beat the Orange by only 7 points. Syracuse's worst defeat before tonight was to North Carolina, on the road, by 24 points; later, at home, Syracuse won by 12. So the margin is truly impressive, especially considering that Stanford won its game tonight by only 12 or so.
It should be noted that the margin of victory in tonight's game exceeded either the Championship game in 2016 (with Stewie and company) or the 2017 victory in the same round of the NCAA tournament at Storrs. I re-watched the 2017 game last night and it looked like a complete beatdown, despite Syracuse having good players like Brittany Sykes and Alexis Peterson in that game. But tonight was an even bigger margin. (Of course, I don't think this year's Orange team is as good as its 2017 team.)
I was also REALLY impressed by how well the UConn offense ripped apart the Syracuse zone defense once they got the hang of it in the third quarter. Every point UConn scored in that quarter was in the paint, according to the announcers. Considering that Syracuse has played that zone all year against what should have been good ACC competition, whereas UConn was facing it for the first time in this game, that was and is a serious accomplishment.