As several others have mentioned, a high ankle sprain takes a few weeks to heal.
Good news is that there's a 12 day stretch with only the home game against Houston. I would like him to be ready for Cincy, but if he isn't you move on without him. After Cincy is a road game against UCF which doesn't worry me.
Bottom line is that if he has to miss Houston, @Cincy and @UCF in order to be healthy for the rest of the season, conference tourney and NCAA's, then I'm okay. Even without him UConn should go 2-1 at worst.
Just from past experience, if it's a standard, run of the mill high ankle sprain, I think the 2/12 home game against USF is his first game back so that he has the rust knocked off before the Memphis game on 2/15.