Per SportsMD: A midfoot sprain is an injury to the ligaments of the central region of the foot, known as the midfoot. It is a common injury that occurs during athletics, in particular those sports where there is cutting and twisting that can lead to this injury. It can cause an athlete to miss considerable time from his or her season.
Midfoot sprains are most commonly a momentary stretch of a ligament that subsequently recoils to its original length and is therefore a grade 1 injury. More severe, and less common, injuries may cause a partial (grade 2) or complete (grade 3) ligament rupture. In these cases, the injury is more severe as the ligament does not return to its original length, and the bones it holds together can separate. This is the definition of an unstable injury that usually requires a surgery to repair.
A mild, grade 1, midfoot sprain can be managed non-operatively with a short period of immobilization in a hard-soled shoe or a removable boot. A short period of limited weight-bearing may be necessary to allow the ligament to heal and therefore the swelling and pain to subside. Regular icing, elevation and non-steroidal anti-inflammatory medications (NSAIDS) are both important to treat the swelling along with the pain. In most of these cases, the athlete will be able to return to participating in their sport in anywhere from a week to a few months.
The Lisfranc injury is a midfoot sprain, that occurs if a bone in the middle of the foot has been broken, or ligaments supporting the bone have been torn.