A team's résumé is defined primarily by wins, not losses. The committee has consistently shown that a quality helps a team more than an unexpected loss hurts it.
Notre Dame has 5 RPI top 25 wins (ranking in parentheses):
Louisville (3), Marquette (10), Iowa (11), Gonzaga (13), Drake (15)
(Notre Dame also has a high-quality win over Oregon State, whom the committee will regard more highly than their current #37 RPI ranking would suggest.)
Compared to 3 RPI top 25 wins for UConn:
ND (1), UCF (16), Cal (22)
People are making way too much of ND's loss to an "unranked" team—at least in terms of its impact on seeding. The committee can and will be very cognizant of the fact that ND was missing a key starter for that game, provided that Jackie Young returns to the team and is available for the postseason.