I don't think UConn has the pitching depth to go through the losing bracket in a post season tournament. For one thing, you need a dependable fourth starter who can give you some innings, or more bullpen arms you can rely on.
In terms of the toughness of going through the losers bracket, this really only applies to the conference tournament and the first weekend 4 team regional pods of the first round of the NCAA baseball tournament. The second weekend the format changes to a best of 3 series between 2 teams, so there is no loser's bracket to be had. And the 8 team college world series in Omaha which is a double elimination tournament takes over a week to complete as well, so games are not piled on high next to each other. I kind of like the changing formats of each part of the tournament, as it means each team has to adjust to that particular format. And as they say, baseball is a game of adjustments.