I posted this on another thread, but it's pertinent here, too.
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In 2019, Louisville was the #1 seed in Bridgeport. In the same regional, UConn was #2. Mississippi State was the #1 seed in Portland, with Oregon as #2. Baylor was the #1 seed in Greensboro with NC State at #3 and SC at #4.
In 2018, Notre Dame was the #1 seed in Spokane. In the same regional, Oregon was #2.
In 2017, Note Dame was the #1 seed in Lexington, KY (their closest regional), but they let Kentucky stay home as the #4 seed.
In 2016, Notre Dame was the #1 seed in Lexington, KY (their closest regional), but they let Kentucky stay home as the #3 seed.
Then, going back to 2000 and just looking at UConn's seeding/parings...
In 2014, UConn was the #1 seed in Lincoln, NE. In the same regional, Nebraska was the #4 and Oklahoma was the #10. Same year, South Carolina was the #1 seed ON STANFORD'S HOME FLOOR with Stanford as the #2 seed.
In 2010, UConn was the #1 seed in Dayton, OH. In the same regional, Ohio State was the #2 seed.
In 2007, UConn was the #1 seed in Fresno, CA. In the same regional, Stanford was the #2 seed.
In 2003, UConn was the #1 seed in Dayton, OH. In the same regional, Purdue (~3 hours from Dayton) was the #2 seed. Same, year, LSU was the #1 seed on Stanford's home floor with Stanford as the #3 seed.
In 2000, UConn was the #1 seed in Richmond, VA. In the same regional, Duke (~2 from Richmond) was the #2 seed.
I know that the considerations that go into seeding and placement have evolved over the years, but putting a #1 seed in the backyard of a #2 (3... 4...) seed happens to more than just #1 seeds coming to the northeast. Money talks everywhere to the NCAA.