Yes, because finding a 100s OOC game in the sea of 300-rated-teams is a bit hard. See how that works?
So - since everyone is pointing at the Houston L - let's see how this impacts vs OOC SOS:
UConn now - 69 RPI / 70 SOS
w/ Houston flipped to W: 54 / 63
Now, I'll replace Houston completely with a 2nd instance of South Florida (similar RPI, 186 OOC SOS)
UConn now (ie swap @Houston L for an @USF L) - 68/63
w/ @USF flipped to W: 54/63
Our SOS jumps 10 points based on 1 away game for teams that are both essentially the same, minus OOC SOS. The RPI stays flat because it impacts the bigger measure of RPI (opponent W/L is 50%, and we would play them twice, vs once for Houston) Extrapolate this across the whole conference, and you can see where I'm going.
It's not a perfect calculation (knock-on impact of flipping the game), but i would call this a statistically significant "net impact"