Hartford/central CT like many locations in the north have been unable to reposition themselves in a world where people are migrating largely to four types of areas: A) metro areas of large cultural center cities (Boston, NYC, Washington, LA, San Fran), B) metro areas of small cultural cities (Austin, Portland, Nashville) with warmer weather, C) metro areas of large warm weather cities big enough to support a couple pro teams (Miami, Tampa, Atlanta, Charlotte, Phoenix, etc) and D) outdoor/active cities (Salt Lake, Denver, Seattle). If I had to throw another one out there it would be energy cities: Houston and Dallas, but really those are cultural cities in my book.
Hartford/central CT needs to two prong attack - find a way to become part of group B and reinvigorate its historic position as fall back place for when businesses/people have fatigue/growing pains in NYC and Boston.