Indeed UConn is not the Tennessee LVs of the 2009 tourney. That was a 10-loss team, a five seed.
I think the St John's loss has people spooked a bit. UConn hadn't suffered a loss like that in a long time. Whereas the Baylor and ND losses were understandable, that one was out of the blue and reminded people that yes, on any given night, even UConn can lose to teams it shouldn't. Fortunately, the evidence seems to point to the possibility that the SJU loss, in conjunction with the second ND loss, may have lit a fire under the girls. KML and Bria have bounced back without Tiff regressing, while Stef seems to have found her niche on this team as well.
So yes, anything can happen on any given day, but it would take an exceptionally poor performance by UConn to lose to either Penn State or LSU. And there's nothing wrong with stating a preference; you're not on the team, and empirically, many people's preferences have little to do with the teams per se (see: residual dislike for SEC, "I live in PA", etc.).
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Fun facts about the Sweet 16 below.
Since 1993-1994, UConn's Sweet 16 results have been as follows:
1994- W 78-64 USM
1995- W 87-56 Alabama
1996- W 72-44 USF
1997- W 78-73 Illinois
1998- W 74-57 Arizona
1999- L 58-64 Iowa State
2000- W 102-80 Oklahoma
2001- W 72-58 NC State
2002- W 82-64 Penn State
2003- W 70-49 Boston College
2004- W 63-55 UCSB
2005- L 59-76 Stanford
2006- W 77-75 Georgia
2007- W 78-71 NC State
2008- W 78-63 Old Dominion
2009- W 77-53 Cal
2010- W 74-36 Iowa State
2011- W 68-63 Georgetown
So that's 11 easy wins, five close wins, and two losses (one of which being an upset). Three of the five close wins portended doom in the next round; in fact, all three of those teams were deeply flawed (2006 and 2007 were teams that struggled to have the right pieces with the right amount of experience, 1997 was suffering from the Shea Ralph injury hangover). One went on to win a NC, and one lost in the national semis.
When you get to this point, it's all about matchups and styles of play. I don't think LSU or Penn State match up well with UConn or play a style that would give UConn a lot of problems. Then again, you often do have to pull out one ugly game to make a deep run, so we'll see.