UConn from 2000-2013 (Louisville joined ACC in 2014) had not won a game with a team that was in the ACC that had a winning season...had 5 wins (Duke, Duke, Wake, Wake, Maryland)..11 losses. All of UConn's ACC losses, however, were to an ACC team that had a season's end winning record.
Interestingly, UConn's lowest winning percentage 2000-2013 against conferences was the ACC...had .500 against the Big Ten (4 games) and SEC (4 games)...and .600 against the Big 12 (6 games). Of those 25 games, only the win over South Carolina, 7-6, was over a team with a season record above .500.
I think it may be that the lack of wins that get you noticed may have hindered UConn...beating winning teams gets more respect.