As long as there's 3 shooters on with the two bigs I suspect it'll work. Can be any three of Newton, Hawkins, Calcaterra, Karaban, and possibly Alleyne/Diarra. I think you need the three out to be dangerous from outside to clear space for the two bigs to operate. So I don't think having Jackson with them works.
On the other hand, wouldn't a lineup of Sanogo, Clingan, Karaban, Jackson and Newton be downright scary? Would we ever give up a rebound?
That's not to say I'd do either of them, but if Hurley wants time in the lab to experiment, fine.