From the NCAA tickets site concerning the first round games:
First-, second- and regional rounds will be played earlier in the week, with games on Friday/Sunday and Saturday/Monday. First-round play will take place March 20 and 21, while second-round play will take place March 22 and 23 at non-predetermined sites on the courts of the top 16 seeds. In the event that a top 16 seeded team does not submit a bid to host, or their bid does not meet requirements for hosting, the committee will select a host from the remaining submitted bids that meet requirements. In order to adhere to the bracketing principles, it may not be possible to select the next highest seed to host.
Potential hosts have to have submitted a bid, and with Louisville hosting men's R2 and R3 games on Thursday and Saturday, it may not have been considered doable or even permitted option for the women to host in between with all the changes that would be needed to switch the banners around and work around practice time. I cannot think of any disqualifying issues with UWGB hosting in this situation as the two teams have not played each other this year. Clearly, Creme has been apprised of the situation about the bids, because one thing he is is very meticulous.