Agree with those that say it depends greatly on who you are playing with, and the opponents lineup at the time. On the other hand some sites compute on and off plus minus statistics which have considerably more value but still some flaws. They look at the plus minus stats while you are in the game and compare it to when you are not, and then take the difference.
Taken in context with many other stats I think it has some value, but more based on a season than an individual game. I think the best overall comprehensive stat is the plus/minus at Sports-Reference.com. PER is very good too, but is measured against the competition you play with 15 being average. The problem is comparing players that have faced very different competition. A player in one of the weakest conferences might have a PER of 25 against their competition, but maybe it only would have been 15 if they played in a power 4 conference for example. The other issue is no adjusting for pace. Fast paced teams put up bigger numbers across the board in most categories.
Sports-Reference.com for their college basketball adjusts for both of those factors. In their case, the data they use is the totals from all the division 1 schools in all categories. Then the player's stats are adjusted for the pace of the team. Increasing them if they played on a slow pace team, and decreasing them on a real go go team so they are on a level playing field. Then a similar adjustment is made for the level of competition, increasing them if obtained against top competition, and decreasing them if they played in one of the weakest conferences.
In the end, as I understand it, their plus/minus is an estimate of how many extra points a player produces when compared to the average division 1 player, playing average competition, per 100 possessions. Now the average number of possessions per game I think is closer to 70, and a starter might be in for say close to 70% or more of a teams possessions, so I consider half of that site's plus minus to be roughly how much a starter would be worth vs. an average division 1 player per game as a ballpark.