I think it comes down to this: when a strong #1 loses in a regular week, how far do they typically fall? Even if teams 2-10 all win, they aren't dropping to 10. I haven't done the math, but my guess is that #1 usually drops somewhere to 3-5 with a loss. But then when 2 and 3 also lose, as well as 5 and 6, it muddies that a great deal, and you have to think more because holistically about who gets ranked where. I can see some reverting to resume. It's a weird week.
I ultimately think the Top 4 is going to be Purdue/UConn and then Kansas/UNC. It could come in almost any order within that split (i.e. might be UConn-Purdue-Kansas-UNC or Purdue-UConn-UNC-Kansas, etc).