Novocaine. Stairs Jack Quaid as Nathan Caine, a bank manager who has a genetic disorder and cannot feel any pain. He falls for Sherry (Amber Midthunder from Prey) who works at the bank. The bank is robbed, she is taken hostage. So Caine goes after the guys to retrieve her and because he can't feel pain, takes an enormous amount of physical abuse in the process. This is where you suspend disbelief, because pain or no pain, concussions occur and damage can limit your abilities. Still this is fun once you get past that and quite humorous at times. Quaid is really perfect for this role.
@CL82 my mind immediately went to the parallels of the Winter Mantle effects on Dresden and this is somewhat similar.