I'm a little nervous about this game as an ND fan. Tennessee will be embarrassed at having lost to Arkansas and they will be highly motivated. They certainly have the talent to trouble ND.
However, they would need to turn the ball over far less and shoot much better than they have been in order to beat ND. I don't see how they can suddenly make that happen. Also, even if Tennessee does experience some success early on in the game, Muffet can and will change the game plan. This has happened against Duke in the past where Duke had a good game plan but couldn't counter Muffet's response. This seems to be a problem for Tennessee. When Plan A doesn't work, they don't have a plan B.
Finally, the received wisdom on Tennessee is that they struggle against teams who a) can break their press & b) play an effective zone. ND has done very well against presses this year. For example, see the DePaul game. DePaul tried to press in the first half and ND ended up with a 26-point halftime lead. Zone is always a part of ND's defensive arsenal and they probably have more practice with it this year than in most year's because they used it a quite a bit when Turner was out. I don't know if they'll run it from the start but they certainly won't hesitate to use it if need be.
If they depend on the press generating turnovers and on man-to-man defense to score, I don't think they'll score much more than usual. And if they don't score more than usual, I don't see them winning.
So I'm nervous but from a rational perspective I expect ND to win by high single digits or low double digits. I think Tennessee's best chances to win are for ND's bigs to get in foul trouble and/or DeShields to catch fire.