@UConnTrumbull , I sent you a PM with the compilation of my food and music recommendations. If you can tell me when you are going and for how many nights I can give better input on hotels, but in general my preference in recent years has been the downtown/warehouse district, which is pretty central to any place you'd want to walk.
It's a great city to Priceline for 4-star hotels because there are so few zones that have them that you can bid repeatedly by adding zones that you know do not have them and increase your bid incrementally. I've stayed in almost all of the 4-stars in those areas and am happy in any of them. On our most recent stay I couldn't do Priceline or Hotwire because there were so many of us that wanted to be at the same hotel, but with different arrivals and departure, so after much research we settled on the Drury Inn & Suites and were very happy (we all got suites). If the price is right I would definitely stay there again. Great location, clean, quiet rooms with good space. Nice rooftop pool. Mellow scene. The nearby Ace hotel can be very pricey (but has some deals) and very hipster, but I gotta admit that their rooftop pool and bar area is a very cool spot to hang out. If you can swing it, I'd bet that would be a great spot for your purposes, with a much younger scene than the Drury, if the scene at your hotel matters to you. Most of the time it doesn't matter to me.
As for other advice, avoid ever walking alone, even in seemingly safe parts of the city. It transitions very quickly and with no notice. It is a great city for Uber and Lyft.