I was one of the subjects in the SmithKline study, later finding out that I got the actual vaccine rather than the control. I've also contracted Lyme disease three times, a consequence of orienteering and wilderness travel. The first time was in 1984 from a tick in East Lyme. I actually lived in Ithaca, NY at the time and I needed to "suggest" to the doctor what was happening and the treatment.
IF you can identify the infection early and IF you have a good immune system Lyme disease is not a problem. The longer it takes to identify it, or the more problems one has with their immune system, the worse the consequences of Lyme disease. Incidentally, spirochetes such as the bacterium associated with Lyme disease have a high coincidence with dementia, up to 90%. Most of the time the spirochete is the one associated with gum disease (take great care of your gums), but can be the one associated with Lyme as well. It's not obvious to me whether spirochetes compromise the immune system, which in turn creates an easier path towards dementia, or whether the compromised immune system associated with dementia prevents it from dealing with spirochetes. Does anyone else know?