To keep this thread-relevant, the law would allow a private citizen to cite the law as a reason for not serving another private citizen due to religious beliefs (this makes it different from other similarly named laws, no other state allows for it to apply to private citizens), so a hotel or a restaurant could decide it doesn't want to serve any players who are X because X offends their religious beliefs regardless of what X is.
So, a team would have to call ahead to every place it planned to be in Indiana and check to see if there would be a problem, which would be a huge headache. I can't imagine a major hotel chain would allow this to be a problem, but a small hotel near a smaller school hosting an out-of-state school? Definitely could be a problem.