Pretty much every grunge band other than Pearl Jam lost their lead singer. I was just never much of a fan of Nirvana, hype train was on overdrive with those guys. Much preferred Alice In Chains and Soundgarden.
As an aside, 80s metal bands have been surprisingly resilient by comparison. Lost a few to OD or car crashes or something, but many are still around.
Sandy Denny, lead singer of Fairport Convention, wrote the often covered Who Knows Where the Time Goes at 19. She died at 31 following an accident.