Louisville will not be ranked 4 after getting shalacked by UCONN 3 times. They will need to compete closely and I don't think they will.
Even with three more losses, if the Cardinals do manage to keep at least one of games pretty close and the Yum game was say a 10 point margin, that could be a strong boost for them, with many of the main contenders getting elsewise beat up in conference play and maybe losing games to some more middling teams. Losing to KY is no longer seeming as much like a decent loss, however, but UConn did get a #1 seed last year with 4 losses, though they were to the top two ranked teams. Each year the credentials for a #1 seed change a bit as the situations at the top vary.