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Message: [QUOTE="pj, post: 3433723, member: 2524"] As a matter of fact, it has been shown that midlife and younger systemic infections and systemic inflammation measured by inflammatory markers such as CRP are associated with development of Alzheimer's disease 25-40 years later. These conditions are also known causes of irritability and anger. Here is a review: [URL="https://www.ncbi.nlm.nih.gov/pubmed/23046210"]Review: systemic inflammation and Alzheimer's disease. - PubMed - NCBI[/URL]. [/QUOTE]