What's really remarkable is how they've lost every type of game in every possible way. You have disheartening rivalry losses (BC in '05, Providence in '22), inexplicable duds turned in by great teams (Marquette in '06, Georgetown in '09, Houston in '14, maybe last night), games that set the stage for disappointing seasons (WVU in '07, Temple in '15, pretty much every loss that occurred between '17 and '20), and then sheer heart-breakers (Cincy in '10, Marquette in '13, Creighton in '21). The most normal conference opener they've lost might've been Pitt in 2011, and that was a national champ losing by 15.
Oddly, most of the victories prior to last year (Hall in '08, USF in '12, Tulane in '16) came during mostly forgettable seasons.