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Message: [QUOTE="UcMiami, post: 3474332, member: 199"] The flu mutates quite rapidly partly because it reproduces/spreads so rapidly - the hypothesis is there was a mutation to more virulent strains between 1917 and 1918/19. The likelihood is that the second wave did not infect the same people as those who survived the first wave probably had greater immunity to the next waves. Hard to judge the Sars viruses as they have not had the same level of human migration/mutations. Interesting situation with flu vaccines that many people do not realize - early on each year a group of laboratories determine the most likely strains of virus that will spread during the coming season and create a vaccine aimed at the most likely individual strains and pray they covered the bases for the coming year as the vaccine goes into production and gets released to the public six months later - some years they nail it, some years not so much. [URL unfurl="true"]https://www.cdc.gov/flu/prevent/vaccine-selection.htm[/URL] [/QUOTE]