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Message: [QUOTE="ctchamps, post: 3499477, member: 37"] I'm making a leap based on the statements of two British researchers. They postulate that there might be two modalities in which the med works. The first postulation is that the med might be binding to a sugar molecule on the cell membrane which is the binding site of the virus. That keeps the virus from binding and infecting. Here is a link to how our bodies defend against a virus. [URL='https://www.ncbi.nlm.nih.gov/books/NBK8423/']Immune Defenses[/URL] It's amazing how many defenses we have to keep us healthy. Most likely the body probably will react to the free floating virus and begin making antibodies. The question is whether cell destruction by the virus would elicit a better immune response and with it a longer immunity. I'm sure that will be debated. There is evidence that an over active immune response might be a major contributor to why some people are becoming severely ill. Several studies are underway to find medications to lesson the over reaction. My concern is the second modality. After binding with the membrane the virus is encapsulated as it passes through and enters the cell. The British researchers postulate hydroxychloroquine elevates the ph of the cell fluid preventing the virus from exiting the capsule preventing it from taking over the cells DNA. That seems good but the virus is still in the cell not getting destroyed. If this is the case, and that's a big if, the cells are keeping the body from developing an immune response by sequestering them (talk about ironies). When the medication is discontinued the ph will return to normal resulting in the virus taking over the cell. They cause the cell's machinery to make large numbers of them. They then rupture the cell releasing themselves to infect adjacent cells. When enough cells get destroyed and a person sneezes, coughs or talks the virus is release into the environment. If I'm correct (and I hope I'm not) giving this medicine to infected people will incubate the virus during the entire time the patient is on the medicine (because of this sequestering). Once those individuals get off the medication they become infectious to others. These drugs have some toxicity so we won't want to keep people on the meds indefinitely. And given that no one is discussing the possibility I'm describing I'm concerned we are creating a large group of infectious people who will reinfect us just as the pandemic appears to be getting under control. [/QUOTE]

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