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Message: [QUOTE="Rocktheworld, post: 2412946, member: 5037"] Drugs ultimately course through the blood, which flows through the entire brain. PCP use on its own “affects” all regions of the brain essentially equally in its toxicity. I imagine that’s why a more global cognitive impairment, rather than a kind of “component” impairment (in specifically attention, or spatial processing, or language, etc.) in those with a histories of lengthy substance abuse. But when you superimpose that on to pre-exposure damage in the brain, said damaged areas (and again this just makes intuitive sense to me) should be extra-susceptible to those toxins to where at the very least recovery at the anatomical level will be reduced. Then you think about how the C part of CTE necessitates repeated trauma, you get an exacerbated compounding effect where concussion 4 for Hernandez could be way worse than concussion 4 for a non-user But of course there are other factors related to the injuries themselves as well [/QUOTE]