Yes Yes Yes. I don't see any problem starting Azzi at pg taken in isolation. But a few consequences will follow, and Geno may think these are worth the risk.
First, I don't think it makes much sense to start Nika as an sg next to Azzi, then. But starting Lou at the 2 or the 3 means we have less experience running our defensive schemes. This may be what he meant by saying "we may need to win some games 100-97."
Second, Geno might end up running an offense-defense platoon with Nika and Lou. My guess, uninformed as it is, would be that Lou would get more minutes in that role than Nika, but Nika would get some additional minutes spelling Azzi at pg. But Nika is a resourceful player who finds herself in the oddest matchups -- in the Indiana game, for example, she guarded Holmes under the rim on a couple of occasions and was strong enough to keep her from simply posting her up. Who would have imagined little Nika holding off a very skilled post and denying the entry pass at the same time?
Third, Caroline would end up playing effectively at the wing, since she is an experienced (and sometimes devastating) defensive player. This is clearly a role Lou can play as well if pressed, and Aubrey and Ayanna may get a few minutes there, too.
I guess this is how he'll think about the "positionless" scheme this year, that we're running a 3 guard offense, but they blur into something more like a 1/2, a 2/3, and a 3/4. One thing such a scheme might do is open up a few minutes for Ines when we simply want a pure pg on the floor.