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The circadian rhythm regulates sleep-wake cycles and repeats every 24 hours. It is endogenous but is adjusted to the local environment by external cues such as light, temperature, and something called redox cycles which is a type of chemical reactionin which the oxidation states of atoms are changed (see wikipedia) . This is relevant to the UCONN - Arizona semifinal game in several ways. First, being a West Coast time zone location, a 9:30pm start (Eastern time) is the equivalent of 6:30 pm for Arizona compared to 9:30 for UCONN as an East Coast time zone 3hours ahead of the West Coast time zone. Second, because of the isolation of the teams in the "bubble" there were fewer environmental cues to allow for adjustment to the time change for UCONN. Several coaches have described the relative lack of opportunity to be outside except while transitioning from dorm to gym and back. I am not a sleep expert, but it is a safe assumption that UCONN was less adjusted to a late game start (9:30 pm) than Arizona, and thus more susceptible to fatigue and lack of focus and mental sharpness. Relatively speaking, it was clear which team looked more energetic and focused. This is perhaps a factor to take into account when the ESPN's of the world schedule games this late in the day. As teenagers and young adults are in even greater need of proper sleep than adults, a team with 7 freshmen is going to be even more impacted by disrupted sleep cycles. Food for thought.