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Message: [QUOTE="JustbrewitMan, post: 3480929, member: 7806"] Hey pj, Similar evolution towards less-virulent strains has occurred with many human-infecting viruses including influenzae, and the original SARS virus (Strains in the few cases post 2002-3 were much less virulent). I think that there's evidence that this is already happening again naturally. In perusing bioRxiv.org this AM, there are a couple new non-peer-reviewed articles that, through skimming the abstracts, are suggesting this in some strains within and outside of China. Haven't read them completely though. There's also another non-peer-reviewed article I'm going to dive into later that seems to show that through protein structure modeling, that the SARS-CoV-1 and SARS-CoV-2 viruses, though only showing [B]72.8% sequence identity [/B]of receptor-binding domains, had [B]97% structural similarity [/B]of those areas. [URL unfurl="true"]https://www.biorxiv.org/content/10.1101/2020.03.10.986398v1.full.pdf[/URL] Agree that we all may interpret things quite differently in as shortly as 2-4 weeks as new data furiously emerges. I'm a little worried and fascinated about some of the new VERY PRELIMINARY suggestive concerns for relationships between people with higher-ACE2 states (hypertension, poorly-controlled diabetes, possibly obesity, as well as people receiving various cardiovascular/kidney disease with ACE inhibitors and/or Angiotensin Receptor Blockers (ARBs) and more severe COVID-19 infections / higher mortality It's a bit too early to say whether people should stop taking these medications yet / switch to some other class of antihypertensive medication ([B][SIZE=5]so people, PLEASE PLEASE don't do this on your own![/SIZE][/B]) in the face of the COVID-19 pandemic...but its something to watch closely. [/QUOTE]

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