Can they play it? yes. Will they play it? who knows.
Should they play this for extensive periods of time? Hell no. This team would get destroyed on the perimeter.
Short answer is no, I don't think Akok can effectively defend a perimeter player all that well. Truthfully, out of Martin, Akok, Sanogo and Whaley, Whaley is by far the best perimeter defender. And that's especially true on pick and rolls and pick and pop plays.
As much as we fans have been having with lineups based on offense we also have to figure out defensively what makes sense. Good, bad or otherwise, Cole will always have trouble with athletic guards and from what we saw last year, Sanogo will get drilled tot he bench trying to defend the perimeter. So, you have to have a better athlete paired with Cole on the backcourt to defend the better athlete of the opponent, you need a solid wing defender and you need your other 4/5 who is paired with Sanogo to be able to defend on the perimeter.